一种脑肿瘤磁共振对比剂及其制备方法

Brain tumor magnetic resonance contrast agent and its preparation method

Abstract

本发明提供了一种脑肿瘤磁共振对比剂,它是偶联转铁蛋白的超顺磁性氧化铁纳米粒,可含有生理可接受的稀释剂,其稀释剂可以是PBS缓冲液或生理盐水,偶联转铁蛋白的超顺磁性氧化铁纳米粒与稀释剂的重量/体积用量比为10-20mg∶1mL,所述的超顺磁性氧化铁纳米粒可以是超顺磁性三氧化二铁纳米粒或超顺磁性四氧化三铁纳米粒,超顺磁性氧化铁纳米粒的粒径大小为10~20纳米。本发明对比剂利用转铁蛋白与表面表达转铁蛋白受体的细胞的高亲和力来实现靶向性显影,具有特异性高、选择性好、对比效果强、毒副作用低、组织浓度足够活体成像等特点。
The invention provides a brain tumor magnetic resonance contrast agent. The contrast agent is transferrin coupled super-paramagnetic iron oxide nanoparticles and contains a physiologically acceptable diluent, wherein the diluent can be PBS (phosphate buffer solution) or normal saline; the weight/volume application ratio of the transferrin coupled super-paramagnetic iron oxide nanoparticles to the diluent is 10-20mg:1mL; the super-paramagnetic iron oxide nanoparticles can be super-paramagnetic ferric oxide nanoparticles or super-paramagnetic ferriferrous oxide nanoparticles; and the particle sizes of the super-paramagnetic iron oxide nanoparticles are 10-20nm. The contrast agent utilizes the high affinity between the transferrin and transferrin acceptors expressed on surfaces of cells to realize the targeting developing, and has the characteristics of high specificity, good selectivity, strong contrast effect, low toxic side effect, enough tissue concentration for the in-vivo imaging, and the like.

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    谢辉等: "偶联乳铁蛋白的超顺磁性氧化铁纳米粒对大鼠脑胶质瘤的成像研究", 《生物物理学报》, no. 1, 15 July 2009 (2009-07-15)

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